Is Iron Safe with Quinapril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not take iron supplements within 2 hours of quinapril. Separate doses by at least 2 hours, preferably taking quinapril on an empty stomach. Failure to separate may significantly reduce blood pressure control.
Why this interaction occurs
Iron forms insoluble chelation complexes specifically with quinapril, reducing quinapril bioavailability by up to 37% according to pharmacokinetic studies. This is uniquely significant among ACE inhibitors due to quinapril's chemical structure and is well-documented in clinical literature.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 9,603 reports mentioning Quinapril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Quinapril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Iron interactions → · All Quinapril interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.