Is Iron Safe with Lisinopril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Take iron supplements at least 2 hours before or after Lisinopril to prevent absorption interference. Do not adjust your blood pressure medication schedule without consulting your pharmacist or physician.
Why this interaction occurs
Ferrous sulfate and other iron salts can form chelation complexes with Lisinopril in the gastrointestinal tract, reducing the bioavailability of the ACE inhibitor by up to 44% in pharmacokinetic studies. This may lead to subtherapeutic blood pressure control.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 323,131 reports mentioning Lisinopril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Lisinopril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Iron interactions → · All Lisinopril interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.