Is Kaolin-pectin Safe with digoxin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid taking kaolin-pectin (found in some anti-diarrheal products) at the same time as digoxin. Consult your doctor if you need to use it, so digoxin levels can be monitored and dose adjusted if necessary.
Why this interaction occurs
The FDA label lists kaolin-pectin as a substance that decreases digoxin concentrations, recommending monitoring and a possible dose increase of approximately 20 to 40% as necessary.
Evidence
Evidence level: strong.
Data source
FDA Drug Label (OpenFDA)
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 64,171 reports mentioning digoxin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the digoxin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Kaolin-pectin interactions → · All digoxin interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.