Is Kava Safe with Hydroxyzine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid kava while taking hydroxyzine. This combination can cause dangerous over-sedation. Report any breathing difficulty or extreme drowsiness to your prescriber immediately.
Why this interaction occurs
Hydroxyzine is a first-generation antihistamine with significant CNS depressant, anticholinergic, and anxiolytic effects. Combined with kava's GABAergic and CNS-depressant properties, there is a meaningful risk of profound sedation and respiratory compromise.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 58,323 reports mentioning Hydroxyzine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Hydroxyzine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Kava interactions → · All Hydroxyzine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.