Is Magnesium Safe with Hydroxyzine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Magnesium supplementation at dietary doses (200–400 mg/day) is generally safe but inform your prescriber. Monitor for increased drowsiness. Avoid high-dose magnesium without medical supervision.
Why this interaction occurs
Magnesium acts as a natural NMDA receptor antagonist and has mild anxiolytic and sedative properties. When combined with hydroxyzine, low-level additive CNS depression may occur. At standard supplemental doses the risk is low, but high-dose magnesium may amplify sedation.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 58,323 reports mentioning Hydroxyzine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Hydroxyzine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Hydroxyzine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.