Is Kava Safe with Clonazepam?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid this combination entirely. Discontinue kava and notify your prescriber. Do not drive or operate machinery. Seek emergency help if breathing becomes slow or labored.
Why this interaction occurs
Clonazepam potentiates GABAergic inhibition at GABA-A receptors. Kava kavalactones independently modulate GABA-A receptors and inhibit voltage-gated sodium channels, compounding CNS depressant effects and raising the risk of life-threatening respiratory depression.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 122,823 reports mentioning Clonazepam. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Clonazepam + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Kava interactions → · All Clonazepam interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.