Is L-Arginine Safe with Atenolol?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor blood pressure when combining these agents. Sit or stand slowly to reduce orthostatic hypotension risk. Inform your doctor before starting L-Arginine supplementation.
Why this interaction occurs
L-Arginine promotes nitric oxide-mediated vasodilation, which combined with the blood pressure-lowering effect of beta-blockers like atenolol, can produce additive hypotension. Athletes or patients taking high-dose L-Arginine are at increased risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 128,375 reports mentioning Atenolol. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Atenolol + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All L-Arginine interactions → · All Atenolol interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.