Is L-Arginine Safe with Losartan?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor blood pressure frequently if using both. Discuss supplementation with your prescribing physician. Reduce or discontinue L-Arginine if hypotension symptoms develop.
Why this interaction occurs
L-Arginine enhances endothelial nitric oxide production, causing vasodilation and blood pressure reduction. Combined with ARBs like losartan, which block angiotensin II-mediated vasoconstriction, additive antihypertensive effects can result in excessive blood pressure lowering.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 196,849 reports mentioning Losartan. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Losartan + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All L-Arginine interactions → · All Losartan interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.