Is Melatonin Safe with Fluvoxamine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining fluvoxamine with melatonin supplements unless under direct medical supervision. If prescribed together, use the lowest effective melatonin dose (0.5 mg or less) and monitor closely for excessive sedation.
Why this interaction occurs
Fluvoxamine is a potent inhibitor of CYP1A2, the primary enzyme responsible for melatonin metabolism. Co-administration can increase melatonin plasma concentrations by up to 17-fold, leading to prolonged and excessive sedation, psychomotor impairment, and disruption of circadian rhythm regulation.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 6,443 reports mentioning Fluvoxamine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Fluvoxamine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Melatonin interactions → · All Fluvoxamine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.