Is Melatonin Safe with Clonazepam?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
If melatonin is needed for sleep, use the lowest effective dose and take only at night. Inform your prescriber. Monitor for excessive drowsiness, coordination problems, or memory difficulties.
Why this interaction occurs
Melatonin's sedating effects are additive to the CNS depressant profile of clonazepam. Clinical studies suggest melatonin can augment sedation in benzodiazepine users, potentially impairing cognitive function and reaction time.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 122,823 reports mentioning Clonazepam. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Clonazepam + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Melatonin interactions → · All Clonazepam interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.