Is Melatonin Safe with Risperidone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Melatonin can be used cautiously at low doses (0.5–1 mg). Monitor for increased sedation or dizziness, particularly during the first few days of concurrent use. Inform your prescriber before starting melatonin.
Why this interaction occurs
Risperidone has moderate sedative properties and may mildly potentiate the sedative effects of melatonin.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 63,944 reports mentioning Risperidone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Risperidone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Melatonin interactions → · All Risperidone interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.