Is Milk Thistle Safe with Valsartan?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use caution combining Milk Thistle with Valsartan. Milk Thistle may mildly slow Valsartan metabolism via CYP2C9. Monitor for increased side effects.
Why this interaction occurs
Silymarin inhibits CYP2C9 in vitro — clinical significance unclear. Result: slightly increased drug levels.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 76,610 reports mentioning Valsartan. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Valsartan + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Milk Thistle interactions → · All Valsartan interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.