Is St. John's Wort Safe with Valsartan?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Mention supplement use to your care team. Valsartan is largely eliminated unchanged; clinically meaningful interaction is unlikely but not fully excluded.
Why this interaction occurs
Valsartan is minimally CYP-metabolized (largely eliminated unchanged; OATP substrate). St. John's Wort is not expected to meaningfully alter valsartan levels via CYP induction. Phenoconversion risk is minimal for this pair.
Evidence
Evidence level: strong.
Data source
FDA valsartan labeling; OATP/CYP substrate literature
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 76,610 reports mentioning Valsartan. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Valsartan + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All St. John's Wort interactions → · All Valsartan interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.