Is Phosphatidylserine Safe with Donepezil?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
May be used together but only under physician supervision. Inform your doctor of all supplements being taken. No dose adjustment is typically required but periodic cognitive assessments are recommended.
Why this interaction occurs
Phosphatidylserine supports neuronal membrane integrity and acetylcholine synthesis. When combined with donepezil, which prevents acetylcholine breakdown, the net effect may be greater cholinergic activity than anticipated. The interaction is generally favorable but unpredictable in individuals with underlying cardiac conditions sensitive to cholinergic tone.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 25,232 reports mentioning Donepezil. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Donepezil + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Phosphatidylserine interactions → · All Donepezil interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.