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Is St. John's Wort Safe with Direct-Acting Oral Anticoagulants (DOACs) — excluding Dabigatran?

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Direct-Acting Oral Anticoagulants (DOACs) — excluding Dabigatran St. John's Wort
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Possible serious interaction — this rule is under review. Ask your pharmacist before combining these.

Evidence

Evidence level: strong.

Data source

PubMed - PMID 31795773

Frequently asked questions

Can I take St. John's Wort with Direct-Acting Oral Anticoagulants (DOACs) — excluding Dabigatran?
Avoid unless your doctor or pharmacist directs otherwise. Possible serious interaction — this rule is under review. Ask your pharmacist before combining these.
How long should I wait between Direct-Acting Oral Anticoagulants (DOACs) — excluding Dabigatran and St. John's Wort?
Possible serious interaction — this rule is under review. Ask your pharmacist before combining these.

Related interactions

St. John's Wort and cyclosporine St. John's Wort and warfarin St. John's Wort and indinavir St. John's Wort and oral contraceptives St. John's Wort and Tricyclic Antidepressants (Amitriptyline, Nortriptyline, Doxepin, Imipramine, Desipramine, Amoxapine) St. John's Wort and Serotonergic Antidepressants (SSRIs, SNRIs) St. John's Wort and CYP450-metabolized drugs (general) St. John's Wort and Sertraline

All St. John's Wort interactions →  ·  All Direct-Acting Oral Anticoagulants (DOACs) — excluding Dabigatran interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.