Check my stack

Is St. John's Wort Safe with Serotonergic Antidepressants (SSRIs, SNRIs)?

⛔ CRITICAL SEVERITY
CHECK MY STACK
Serotonergic Antidepressants (SSRIs, SNRIs) St. John's Wort
Check these in my full stack →

Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Do not combine St. This combination can cause serotonin syndrome, a medical emergency. Stop St. John's Wort and seek immediate medical attention if symptoms such as agitation, tremor, rapid heartbeat, fever, or muscle rigidity occur.

Why this interaction occurs

St. John's Wort has serotonergic activity through inhibition of serotonin reuptake. When combined with SSRIs or SNRIs, additive serotonergic effects can precipitate serotonin syndrome, which is potentially life-threatening. This is a pharmacodynamic interaction.

Evidence

Evidence level: strong.

Data source

PubMed - PMID 41901246

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 4,173 reports mentioning Serotonergic Antidepressants (SSRIs, SNRIs). This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Serotonergic Antidepressants (SSRIs, SNRIs) + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take St. John's Wort with Serotonergic Antidepressants (SSRIs, SNRIs)?
Avoid unless your doctor or pharmacist directs otherwise. Do not combine St. This combination can cause serotonin syndrome, a medical emergency. Stop St. John's Wort and seek immediate medical attention if symptoms such as agitation, tremor, rapid heartbeat, fever, or muscle rigidity occur.

Related interactions

St. John's Wort and cyclosporine St. John's Wort and warfarin St. John's Wort and indinavir St. John's Wort and oral contraceptives St. John's Wort and Tricyclic Antidepressants (Amitriptyline, Nortriptyline, Doxepin, Imipramine, Desipramine, Amoxapine) St. John's Wort and Direct-Acting Oral Anticoagulants (DOACs) — excluding Dabigatran St. John's Wort and CYP450-metabolized drugs (general) St. John's Wort and Sertraline

All St. John's Wort interactions →  ·  All Serotonergic Antidepressants (SSRIs, SNRIs) interactions →

Already checked this one — check your whole list

Check My Full Stack → Generate Visit Packet →
Powered by Elthio Health · elthio.health
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.