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Is Tryptophan Safe with citalopram?

⚠️ HIGH SEVERITY
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citalopram Tryptophan
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Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature

WHAT YOU NEED TO KNOW

Monitor for signs and symptoms of serotonin syndrome. If serotonin syndrome occurs, consider discontinuing citalopram and/or tryptophan.

Why this interaction occurs

Concomitant use of citalopram and tryptophan increases the risk of serotonin syndrome due to additive serotonergic effects.

Evidence

Evidence level: strong.

Data source

FDA Drug Label

Reported safety data

The FDA’s adverse event reporting system (FAERS) has received 113,877 reports mentioning citalopram. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the citalopram + supplement combination on this page.

FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.

Frequently asked questions

Can I take Tryptophan with citalopram?
Avoid unless your doctor or pharmacist directs otherwise. Monitor for signs and symptoms of serotonin syndrome. If serotonin syndrome occurs, consider discontinuing citalopram and/or tryptophan.

Related interactions

St. John's Wort and citalopram Tryptophan and SAM-e Tryptophan and sertraline Tryptophan and fluoxetine Tryptophan and duloxetine Tryptophan and venlafaxine Tryptophan and mirtazapine Tryptophan and trazodone

All Tryptophan interactions →  ·  All citalopram interactions →

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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.