Is St. John's Wort Safe with citalopram?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor for signs and symptoms of serotonin syndrome. If serotonin syndrome occurs, consider discontinuing citalopram and/or St. John's Wort.
Why this interaction occurs
Concomitant use of citalopram and St. John's Wort increases the risk of serotonin syndrome due to additive serotonergic effects.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 113,877 reports mentioning citalopram. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the citalopram + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All St. John's Wort interactions → · All citalopram interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.