Is Urolithin A Safe with Mycophenolate mofetil?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Inform your transplant team before using urolithin A supplements. Monitor for signs of graft rejection or infection.
Why this interaction occurs
Urolithin A is produced by gut microbiota and can in turn reshape the microbiome composition. Since mycophenolate's enterohepatic recirculation and bioavailability are microbiome-dependent, significant microbiome alterations from urolithin A supplementation could affect mycophenolic acid exposure and immunosuppressive efficacy.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 155,005 reports mentioning Mycophenolate mofetil. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Mycophenolate mofetil + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Urolithin A interactions → · All Mycophenolate mofetil interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.