Is Urolithin A Safe with Tacrolimus?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid use in transplant patients without specialist guidance. Tacrolimus trough levels should be closely monitored if used concurrently.
Why this interaction occurs
Urolithin A activates mitophagy and has demonstrated immunomodulatory properties including T-cell regulation. This immune pathway modulation may interfere with tacrolimus-mediated immunosuppression. Additionally, Urolithin A may affect CYP3A4 enzyme activity, potentially altering tacrolimus metabolism and creating unpredictable drug levels.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 130,929 reports mentioning Tacrolimus. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Tacrolimus + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Urolithin A interactions → · All Tacrolimus interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.