Is Urolithin A Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid concurrent use without medical supervision. Inform your prescriber and monitor for signs of unusual bruising or bleeding.
Why this interaction occurs
Urolithin A is a gut-derived metabolite shown to modulate mitochondrial pathways and has demonstrated inhibitory effects on CYP enzymes in preclinical studies. Potential CYP2C9 modulation could reduce warfarin clearance and raise plasma levels, increasing hemorrhagic risk.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Urolithin A interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.