Is Valerian Safe with Eszopiclone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Additive GABAergic sedation is plausible but valerian evidence is thin; eszopiclone labeling warns regarding CNS depressants generally. Use caution.
Why this interaction occurs
Valerian has GABAergic activity that may add to eszopiclone sedation; clinical evidence for this specific pair is limited.
Evidence
Evidence level: moderate.
Data source
FDA eszopiclone label; valerian clinical literature
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 4,524 reports mentioning Eszopiclone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Eszopiclone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Valerian interactions → · All Eszopiclone interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.