Is Melatonin Safe with Eszopiclone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use caution when combining melatonin with eszopiclone. If your doctor approves use, take the lowest effective melatonin dose (0.5–1 mg) and avoid driving or hazardous tasks the next morning.
Why this interaction occurs
Melatonin's MT1/MT2 receptor-mediated sleep promotion adds to eszopiclone's GABA-A receptor sedation, potentially prolonging sleep duration and worsening next-day cognitive and psychomotor performance beyond that seen with eszopiclone alone.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 4,524 reports mentioning Eszopiclone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Eszopiclone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Melatonin interactions → · All Eszopiclone interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.