Is Valerian Safe with Tramadol?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining valerian with tramadol. If you are using valerian for sleep, inform your doctor before taking tramadol. Do not drive or operate machinery if combined.
Why this interaction occurs
Valerian root has sedative properties mediated through GABAergic mechanisms. Combined use with tramadol, which also has CNS depressant effects, can result in additive or synergistic central nervous system depression, increasing risk of excessive sedation, respiratory depression, and impaired psychomotor function.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 219,122 reports mentioning Tramadol. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Tramadol + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Valerian interactions → · All Tramadol interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.