Is Turmeric Safe with Tramadol?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Inform your doctor if you are taking turmeric supplements with tramadol. Watch for signs of increased sedation, dizziness, or nausea. Do not exceed recommended doses of either.
Why this interaction occurs
Curcumin inhibits CYP3A4 and CYP2D6 enzymes responsible for tramadol metabolism to its active analgesic metabolite (O-desmethyltramadol). Inhibition can alter tramadol plasma levels unpredictably, potentially reducing efficacy or increasing parent drug accumulation and serotonergic risk.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 219,122 reports mentioning Tramadol. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Tramadol + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Turmeric interactions → · All Tramadol interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.