Is Vitamin B6 (Pyridoxine) Safe with Prednisone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consider supplementing with 10–25 mg of Vitamin B6 daily during long-term prednisone therapy. Report symptoms such as numbness, tingling, depression, or fatigue to your healthcare provider.
Why this interaction occurs
Prednisone increases the catabolism of pyridoxal phosphate (the active form of B6) and may reduce tissue levels. Vitamin B6 depletion can impair neurotransmitter synthesis, immune function, and homocysteine metabolism, elevating cardiovascular risk in patients on long-term corticosteroids.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 532,790 reports mentioning Prednisone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Prednisone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin B6 (Pyridoxine) interactions → · All Prednisone interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.