Is Calcium Safe with Prednisone?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Take calcium supplementation (1000-1500 mg/day) as directed by your physician to counteract corticosteroid-induced bone loss. Do not stop without medical advice.
Why this interaction occurs
Long-term corticosteroid use causes significant reduction in intestinal calcium absorption and increases renal calcium excretion, leading to osteoporosis and increased fracture risk. Calcium supplementation is a standard preventive measure in chronic prednisone therapy.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 532,790 reports mentioning Prednisone. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Prednisone + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Calcium interactions → · All Prednisone interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.