Is Vitamin D Safe with Gabapentin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Ensure adequate dietary vitamin D intake or consider a low-dose supplement (600–1000 IU/day). Discuss monitoring of vitamin D levels with your doctor if on long-term gabapentin therapy.
Why this interaction occurs
Unlike enzyme-inducing antiepileptics, gabapentin does not significantly induce hepatic enzymes. However, some observational studies have noted modestly reduced 25-OH vitamin D levels in gabapentin users, possibly related to indirect effects on calcium homeostasis or lifestyle factors associated with chronic pain or epilepsy management.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 299,859 reports mentioning Gabapentin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Gabapentin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Vitamin D interactions → · All Gabapentin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.