Is Zinc Safe with Hydrochlorothiazide?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Patients on long-term hydrochlorothiazide should consider periodic zinc status assessment if experiencing symptoms of deficiency (impaired wound healing, taste changes, immune dysfunction). Supplementation of 8–11mg elemental zinc/day may be appropriate if deficiency is confirmed.
Why this interaction occurs
Thiazide diuretics have been shown to increase renal zinc excretion, potentially leading to zinc depletion over time. Zinc is essential for immune function, wound healing, and enzymatic reactions. Long-term thiazide users, particularly the elderly or those with poor dietary intake, are at greatest risk.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 215,975 reports mentioning Hydrochlorothiazide. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Hydrochlorothiazide + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Zinc interactions → · All Hydrochlorothiazide interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.