Is Zinc Safe with Itraconazole?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Separate zinc supplement intake from itraconazole by at least 2 hours. Take itraconazole with food or an acidic beverage and avoid zinc supplementation at the same time to ensure adequate drug levels and antifungal efficacy.
Why this interaction occurs
Zinc supplements, particularly zinc sulfate and zinc oxide, can chelate with itraconazole in the gastrointestinal tract and raise gastric pH, both of which reduce itraconazole absorption. Subtherapeutic itraconazole levels may lead to antifungal treatment failure or development of resistance.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 9,352 reports mentioning Itraconazole. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Itraconazole + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Zinc interactions → · All Itraconazole interactions →
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