Is Calcium Safe with Itraconazole?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Separate itraconazole capsule administration from calcium supplements by at least 2 hours. Take itraconazole capsules with a full meal or cola beverage to maximize absorption. Do not take calcium supplements simultaneously with itraconazole.
Why this interaction occurs
Itraconazole capsule absorption is highly dependent on gastric acidity. Calcium carbonate and other calcium salts can raise gastric pH, significantly reducing itraconazole bioavailability and potentially leading to treatment failure. This is particularly relevant for the capsule formulation, which requires an acidic environment for dissolution.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 9,352 reports mentioning Itraconazole. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Itraconazole + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Calcium interactions → · All Itraconazole interactions →
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