Is Magnesium Safe with Itraconazole?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Separate magnesium supplement doses from itraconazole by at least 2 hours to preserve drug absorption. Ensure magnesium levels remain within normal range, as hypomagnesemia can increase QT prolongation risk associated with itraconazole. Report palpitations or dizziness promptly.
Why this interaction occurs
Magnesium-containing supplements can raise gastric pH and reduce itraconazole capsule dissolution and absorption. Furthermore, itraconazole has a known risk of QT prolongation, and electrolyte imbalances such as hypomagnesemia can compound this cardiac risk. Maintaining normal magnesium levels is important for cardiac safety during itraconazole therapy.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 9,352 reports mentioning Itraconazole. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Itraconazole + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Itraconazole interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.