Is Zinc Safe with Ramipril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Take zinc supplements at least 2 hours before or after Ramipril. Inform your healthcare provider about zinc use, especially if blood pressure becomes difficult to control.
Why this interaction occurs
Ramipril, like other ACE inhibitors, has a zinc-coordinating moiety critical for inhibiting angiotensin-converting enzyme. High-dose zinc supplementation may compete at this binding site. Chronic ACE inhibitor therapy has also been associated with increased renal zinc wasting, creating a paradoxical need-versus-interference dynamic.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 131,310 reports mentioning Ramipril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Ramipril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Zinc interactions → · All Ramipril interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.