Is Zinc Safe with Enalapril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Separate zinc supplement intake by at least 2 hours from Enalapril. Monitor blood pressure regularly and report any changes in symptom control to your physician.
Why this interaction occurs
Enalapril's active metabolite enalaprilat chelates zinc at the ACE active site to exert its antihypertensive effect. Supplemental zinc may theoretically reduce binding efficiency. Concurrent use may also alter the zinc homeostasis, as ACE inhibitors have been linked to increased urinary zinc excretion.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 61,312 reports mentioning Enalapril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Enalapril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Zinc interactions → · All Enalapril interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.