Is Zinc Safe with Lisinopril?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Space zinc supplements at least 2 hours apart from your Lisinopril dose. Discuss long-term zinc supplementation with your doctor, as it may affect blood pressure control.
Why this interaction occurs
Lisinopril contains a zinc-binding group in its active site that is essential for ACE inhibition. Exogenous zinc supplementation may interfere with the drug's binding mechanism and pharmacodynamic activity. Additionally, ACE inhibitors can increase urinary zinc excretion over time, potentially depleting zinc stores.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 323,131 reports mentioning Lisinopril. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Lisinopril + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Zinc interactions → · All Lisinopril interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.