Is Alcohol Safe with zolpidem?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not consume alcohol while taking zolpidem. Alcohol significantly worsens drowsiness, impairs driving ability, and increases the risk of dangerous CNS depression.
Why this interaction occurs
An additive adverse effect on psychomotor performance between alcohol and oral zolpidem has been demonstrated in clinical studies. Concomitant use increases CNS depression and impaired driving ability.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 79,134 reports mentioning zolpidem. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the zolpidem + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Alcohol interactions → · All zolpidem interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.