Is St. John's Wort Safe with zolpidem?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Do not use St. John's Wort while taking zolpidem. Inform your doctor or pharmacist if you are taking this herbal supplement.
Why this interaction occurs
St. John's Wort is a CYP3A4 inducer that may decrease blood levels of zolpidem, potentially reducing its efficacy. Concomitant use is not recommended per the FDA label.
Evidence
Evidence level: strong.
Data source
FDA Drug Label
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 79,134 reports mentioning zolpidem. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the zolpidem + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All St. John's Wort interactions → · All zolpidem interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.