Is Astaxanthin Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid concurrent use of astaxanthin with warfarin. If a patient is already taking astaxanthin, discontinue it and monitor INR closely. Counsel patients on warfarin to report any new supplement use immediately, including antioxidant supplements marketed for cardiovascular health.
Why this interaction occurs
A case report documented INR rising from 1.4 to 10.38 within one day of adding astaxanthin to a stable warfarin regimen, resulting in significant ecchymosis. Causality assessment indicated a probable interaction, though the exact mechanism remains unclear.
Evidence
Evidence level: limited.
Data source
PubMed - PMID 31073352
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Astaxanthin interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.