Is Fish Oil / Krill Oil (Omega-3) Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor INR regularly if using fish oil or krill oil alongside warfarin. While this retrospective study found no statistically significant effect on INR or adverse event incidence in AF/DVT patients, individual variability exists and combined antiplatelet effects warrant ongoing clinical vigilance.
Why this interaction occurs
Fish and krill oil supplementation was studied in warfarin-managed atrial fibrillation and DVT patients. Although significant INR changes or bleeding events were not confirmed in this retrospective analysis, the known platelet-inhibiting properties of omega-3s necessitate continued monitoring given the narrow therapeutic index of warfarin.
Evidence
Evidence level: moderate.
Data source
PubMed - PMID 27657121
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Fish Oil / Krill Oil (Omega-3) interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.