Is Fish Oil (Omega-3 EPA/DHA) Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
If your doctor approves concurrent use of fish oil and warfarin, ensure regular INR monitoring. Report any unusual bruising, bleeding gums, or prolonged bleeding to your healthcare provider promptly. Do not start or stop fish oil without informing your anticoagulation clinic.
Why this interaction occurs
A retrospective study in atrial fibrillation and deep vein thrombosis patients found fish/krill oil did not significantly affect INR or adverse event incidence with warfarin; however, individual variability exists and monitoring remains essential given the known platelet-inhibiting properties of omega-3 fatty acids.
Evidence
Evidence level: limited.
Data source
PubMed - PMID 27657121
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Fish Oil (Omega-3 EPA/DHA) interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.