Is EPA/DHA (Eicosapentaenoic acid / Docosahexaenoic acid supplement) Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Always disclose EPA/DHA or fish oil supplement use to your pharmacist and prescribing physician when taking warfarin. Pharmacist-identified adverse events have occurred with this combination; active medication reconciliation including supplements is essential.
Why this interaction occurs
Concurrent use of EPA/DHA supplements (e.g., Epadel) with warfarin has been associated with recognized adverse events in clinical pharmacy practice, highlighting a clinically meaningful interaction requiring proactive monitoring.
Evidence
Evidence level: moderate.
Data source
PubMed - PMID 32378676
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All EPA/DHA (Eicosapentaenoic acid / Docosahexaenoic acid supplement) interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.