Is Bacopa Monnieri Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid combining without hematologist or cardiologist approval. If already using both, have your INR checked more frequently. Report any unusual bruising, bleeding gums, or blood in urine immediately.
Why this interaction occurs
Bacopa monnieri may inhibit platelet aggregation and has shown CYP2C9 modulatory effects in vitro. CYP2C9 is the primary metabolic pathway for warfarin's S-enantiomer. Inhibition could increase warfarin exposure and raise bleeding risk. The combination warrants close INR monitoring.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Bacopa Monnieri interactions → · All Warfarin interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.