Is Calcium Safe with Voriconazole?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Calcium supplements do not significantly affect voriconazole absorption. Continue prescribed calcium supplementation as directed. Maintain adequate calcium intake to support bone health, especially with prolonged antifungal therapy.
Why this interaction occurs
Voriconazole tablets have adequate bioavailability independent of gastric pH. No clinically significant pharmacokinetic interaction between calcium supplements and voriconazole has been identified in available literature. Patients on long-term voriconazole may require calcium monitoring due to voriconazole-associated periostitis.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 22,258 reports mentioning Voriconazole. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Voriconazole + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Calcium interactions → · All Voriconazole interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.