Is Calcium Safe with Fluconazole?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Fluconazole oral tablets and suspension can generally be taken regardless of calcium supplement timing, as fluconazole absorption is not significantly pH-dependent. Maintain routine calcium supplementation unless otherwise directed.
Why this interaction occurs
No clinically meaningful pharmacokinetic interaction has been established. This is noted for reassurance in patients taking both agents.
Evidence
Evidence level: strong.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 58,684 reports mentioning Fluconazole. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Fluconazole + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Calcium interactions → · All Fluconazole interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.