Is Collagen Safe with Warfarin?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor INR more frequently when starting or stopping collagen supplementation. Inform your anticoagulation clinic about collagen use. Do not discontinue either without consulting your healthcare provider.
Why this interaction occurs
Marine-derived collagen supplements contain vitamin K trace amounts and peptides that may influence platelet aggregation pathways, potentially affecting warfarin's anticoagulant effect and altering INR stability.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 134,328 reports mentioning Warfarin. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Warfarin + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Collagen interactions → · All Warfarin interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.