Is Collagen Safe with Apixaban?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid high-dose collagen supplements (>10g/day) while on apixaban. Report any signs of unusual bleeding such as blood in urine, prolonged bleeding from cuts, or unexplained bruising to your doctor immediately.
Why this interaction occurs
Collagen peptides, particularly type I collagen, are known to activate platelet aggregation via GPVI receptors. Combined use with factor Xa inhibitors like apixaban may unpredictably alter bleeding homeostasis, increasing hemorrhagic risk.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 67,478 reports mentioning Apixaban. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Apixaban + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Collagen interactions → · All Apixaban interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.