Is Magnesium Safe with Hydralazine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Use caution when taking magnesium supplements with hydralazine. Monitor blood pressure regularly. Report symptoms of excessive blood pressure lowering such as dizziness, lightheadedness, or fainting to your doctor.
Why this interaction occurs
Magnesium acts as a natural calcium channel blocker and vasodilator. When combined with hydralazine, which lowers blood pressure through direct arterial vasodilation, there is a risk of additive hypotensive effects. This combination may be particularly pronounced in elderly patients or those on multiple antihypertensive agents.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 37,194 reports mentioning Hydralazine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Hydralazine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Hydralazine interactions →
Already checked this one — check your whole list
Educational only — not medical advice.
Always confirm with your doctor or pharmacist.