Is Potassium Safe with Losartan?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Avoid unless prescribed and monitored. Check potassium.
Why this interaction occurs
Losartan blocks angiotensin II receptors, reducing aldosterone secretion and decreasing renal potassium excretion. Adding exogenous potassium supplements significantly raises the risk of hyperkalemia, which can cause life-threatening cardiac arrhythmias, especially in patients with renal impairment or diabetes.
Evidence
Evidence level: strong.
Data source
FDA COZAAR label; Leong et al., JACC 2019
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 196,849 reports mentioning Losartan. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Losartan + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Potassium interactions → · All Losartan interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.