Is Magnesium Safe with Losartan?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Monitor blood pressure more frequently if starting magnesium supplements while on Losartan. Report dizziness, lightheadedness, or fainting to your healthcare provider. Dose adjustments of Losartan may be needed.
Why this interaction occurs
Magnesium acts as a natural calcium channel antagonist, promoting vascular smooth muscle relaxation and reducing peripheral vascular resistance. When combined with Losartan's antihypertensive effect, additive blood pressure lowering may occur, increasing the risk of hypotension, particularly in volume-depleted patients.
Evidence
Evidence level: moderate.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 196,849 reports mentioning Losartan. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Losartan + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Magnesium interactions → · All Losartan interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.