Is Ergothioneine Safe with Cyclosporine?
Free · No account · based on published sources including NIH ODS, FDA drug labels, and peer-reviewed literature
Consult your transplant physician before adding ergothioneine supplementation. Report any changes in kidney function or signs of rejection.
Why this interaction occurs
Ergothioneine is a potent dietary antioxidant transported by OCTN1 and has shown cytoprotective and immunomodulatory properties. As cyclosporine nephrotoxicity involves oxidative stress pathways, ergothioneine could theoretically mask toxic signals. Additionally, competition at OCTN1 transport sites may alter tissue distribution of cyclosporine in certain cell types.
Evidence
Evidence level: limited.
Reported safety data
The FDA’s adverse event reporting system (FAERS) has received 58,058 reports mentioning Cyclosporine. This reflects reported cases involving the medication in general — not confirmed causation, and not specific to the Cyclosporine + supplement combination on this page.
FAERS reports are voluntary and cannot prove that a drug caused an event. Do not use report counts to assess the safety of this specific drug-supplement pair.
Frequently asked questions
Related interactions
All Ergothioneine interactions → · All Cyclosporine interactions →
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Educational only — not medical advice.
Always confirm with your doctor or pharmacist.